2024 World Conference on Lung Cancer (WCLC) - ePosters-EP.13E.01 Genetic Landscape and Prognostic Markers of Small Cell Lung Cancer: A Comprehensive Study

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The study titled "Genetic Landscape and Prognostic Markers of Small Cell Lung Cancer: A Comprehensive Study" primarily focuses on analyzing genetic mutations and their prognostic significance in Small Cell Lung Cancer (SCLC). The research involved a retrospective analysis of 88 SCLC patients. Using next-generation sequencing, researchers compared genomic profiles between Eastern (Chinese) and Western (Caucasian) populations, examining potential differences in mutation profiles.<br /><br />Key findings include:<br /><br />1. **Prominent Mutations**: The study identified several common mutations, including TP53 in 98%, RB1 in 84%, and LRP1B in 35% of cases. Notably, patients with both TP53 and RB1 mutations had a higher frequency of LRP1B mutations compared to those with only TP53 mutations.<br /><br />2. **Population Differences**: The Western cohort had higher incidences of CSMD3, NAV3, and other gene mutations, while Chinese individuals showed more KMT2D, KMT2C, and PRKDC mutations. The NHEJ pathway mutations were higher in Western patients.<br /><br />3. **Prognostic Markers**: Patients with mutations in the MAPK pathway displayed improved overall survival, whereas mTOR/Ras mutations correlated with reduced progression-free survival in chemotherapy. Females and smokers showed distinct mutation patterns, with females more frequently having EGFR mutations and smokers showing more SMAD4 mutations.<br /><br />4. **Clinical Outcomes**: Improved progression-free survival was noted in patients with high PD-L1 expression undergoing combined chemotherapy and PD-1 or PD-L1 inhibitor treatment.<br /><br />5. **Treatment-Related Observations**: Genetic variations were noted pre- and post-treatment, with certain therapies leading to specific genomic alterations.<br /><br />Overall, the study underscores the genetic complexity of SCLC and highlights important genetic markers that could influence treatment strategies and prognostic outcomes, with distinct differences observed between Eastern and Western populations.

Asset Subtitle

Wenhui Guan

Meta Tag

Speaker Wenhui Guan

Topic Small Cell Lung Cancer and Neuroendocrine Tumors

Keywords

Small Cell Lung Cancer

genetic mutations

prognostic markers

next-generation sequencing

population differences

TP53 mutation

RB1 mutation

MAPK pathway

PD-L1 expression

treatment strategies