2024 World Conference on Lung Cancer (WCLC) - ePosters-EP.13E.04 Racial Disparities in Genomic Subtypes of Small Cell Lung Cancer Patients

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The research conducted by Shirish Gadgeel and colleagues at Henry Ford Health in Michigan investigates racial disparities in the genomic subtypes of Small Cell Lung Cancer (SCLC). SCLC is an aggressive cancer, often detected at an advanced stage, requiring chemotherapy as its primary treatment. Although a comprehensive genomic assessment is challenging due to limited tissue availability, immunohistochemical (IHC) analysis reveals distinct genomic subtypes: ASCL1 (SCLC-A), NEUROD1 (SCLC-N), POU2F3 (SCLC-P), and YAP1 (SCLC-I).<br /><br />The study involved 258 patients diagnosed between 2018 and 2023. Of these, 58 patients provided adequate tissue for analysis, showing a diverse demographic with 9 Black patients and 49 White patients. The data analysis found a higher expression of YAP1 in Black patients' tumors compared to White patients (33% vs. 12%), while POU2F3 and NEUROD1 expressions were more common in tumors from White patients. <br /><br />Moreover, Black patients showed higher positivity for more than one genomic marker. Analysis indicated that patients negative for POU2F3 had a significantly better overall survival rate. However, no differences in survival rates were statistically linked to other markers, and survival analysis between races wasn't possible due to the limited sample size.<br /><br />Conclusions from the study suggest the genomic subtypes of SCLC show differences between Black and White patients, possibly indicating variations in SCLC biology that could have therapeutic implications. These findings necessitate further investigation to confirm initial results and potentially impact treatment strategies across racial groups. The research highlights the need to expand the sample size and conduct further analysis to substantiate these observed disparities.

Asset Subtitle

Fawzi Abu Rous

Meta Tag

Speaker Fawzi Abu Rous

Topic Small Cell Lung Cancer and Neuroendocrine Tumors

Keywords

Small Cell Lung Cancer

SCLC

genomic subtypes

racial disparities

ASCL1

YAP1

POU2F3

NEUROD1

Henry Ford Health

treatment strategies