2024 World Conference on Lung Cancer (WCLC) - ePosters-EP.14A.03 Analyzing the Impact of COVID-19 Infection on Adverse Outcomes in Mesothelioma: A Multicenter Study

EP.14A.03 Analyzing the Impact of COVID-19 Infection on Adverse Outcomes in Mesothelioma: A Multicenter Study

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The study titled "Analyzing the Impact of COVID-19 Infection on Adverse Outcomes in Mesothelioma: A Multicenter Study" aimed to understand how COVID-19 affects treatment outcomes for mesothelioma patients. Prior research had not extensively explored if COVID-19 exacerbated side effects or reduced the efficacy of chemotherapy and immunotherapy in these patients.<br /><br />This research utilized data from the TriNetX database and the US Collaborative Network, involving 60 healthcare organizations. It conducted a propensity-matched retrospective cohort study, comparing mesothelioma treatment outcomes across COVID-19 infected and non-infected patients, matching cohorts on age, race, sex, and comorbidities.<br /><br />Remarkably, despite initial concerns, COVID-19 did not significantly increase mortality among mesothelioma patients. The relative risk of mortality for COVID-19 positive patients was 0.70 at one year and nearly identical to non-COVID patients at 1.03 after three years, indicating resilience to mortality from COVID-19. Furthermore, treatment outcomes, especially immunochemotherapy, showed stability under pandemic stress, with minimal differences in adverse event risks between the groups.<br /><br />However, the study acknowledged certain methodological limitations, such as variability in diagnostic coding and treatment records. These limitations suggest the need for further investigations, particularly regarding long-term COVID-19 effects on inflammation and potential complications in mesothelioma patients.<br /><br />Overall, the analysis reveals encouraging survival trends over two decades, underscoring advancements in treatment protocols, particularly post-2015, while advocating for additional research to deepen understanding of COVID-19's long-lasting influence on mesothelioma.

Asset Subtitle

Aditya Sood

Meta Tag

Speaker Aditya Sood

Topic Mesothelioma, Thymoma, and Other Thoracic Tumors

Keywords

COVID-19

mesothelioma

treatment outcomes

chemotherapy

immunotherapy

mortality

propensity-matched study

TriNetX database

US Collaborative Network

adverse events