2024 World Conference on Lung Cancer (WCLC) - ePosters-EP.14A.06 Outcome of Multimodality Therapy Including Radical Surgical Treatment for Malignant Pleural Mesothelioma at a Japanese Regional Institution

EP.14A.06 Outcome of Multimodality Therapy Including Radical Surgical Treatment for Malignant Pleural Mesothelioma at a Japanese Regional Institution

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The study conducted by R. Waseda and colleagues at Fukuoka University explores the outcomes of multimodal treatment paired with radical surgical procedures for malignant pleural mesothelioma (MPM) at a medium-sized regional institution in Japan. Acknowledging the ongoing debate over the efficacy of surgical therapies for MPM, the study seeks to contribute insights particularly from regional institutions, where fewer cases might provide distinct outcomes compared to larger centers.<br /><br />Between 2009 and 2023, the study reviewed 25 cases out of 110 patients diagnosed with MPM at the institution, focusing on treatment strategies and survival outcomes. These patients underwent either extra pleural pneumonectomy (EPP) or pleurectomy/decortication (P/D), excluding those who had exploratory thoracotomy.<br /><br />Key findings indicate that the patient cohort was predominantly male (24 out of 25), with an average age of 65.2 years. The common pathological type was epithelioid (17 patients). Treatments included EPP (13 cases) and P/D (11 cases), with a shift towards more P/D procedures in the second treatment era (2017-2023).<br /><br />The study reported zero mortality post-surgery, but noted a 20% morbidity rate, with issues like empyema and pneumonia. Importantly, radical treatment achieved macroscopic complete resection in 92% of cases. Survival outcomes showed promising improvement over time, with median survival times increasing from 19.8 months in the first era to 42.3 months in the second, though challenges with long-term survival remain. <br /><br />Overall, the institution’s approach demonstrated acceptable outcomes comparable to larger centers, with improvements in survival over time, suggesting the potential significance of multimodal treatment in regional hospitals. However, bias may exist due to the focused cohort, signaling a need for further research to optimize long-term survival rates.

Asset Subtitle

Ryuichi Waseda

Meta Tag

Speaker Ryuichi Waseda

Topic Mesothelioma, Thymoma, and Other Thoracic Tumors

Keywords

malignant pleural mesothelioma

multimodal treatment

radical surgical procedures

Fukuoka University

extra pleural pneumonectomy

pleurectomy/decortication

macroscopic complete resection

survival outcomes

regional institutions

Japan