2024 World Conference on Lung Cancer (WCLC) - ePosters-EP.14A.18 Single-Center Experience of Hyperthermic Intrathoracic Chemoperfusion for Malignant Mesothelioma

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This study explores the implementation of Hyperthermic Intrathoracic Chemoperfusion (HITHOC) combined with cytoreductive surgery for treating malignant mesothelioma at a single center. Conducted at the University of Pittsburgh Medical Center, the retrospective study covers cases from 2009 to 2022, focusing primarily on surgical outcomes and survival rates associated with this combined therapy.<br /><br />The study involved 38 patients undergoing HITHOC coupled with either pleurectomy with decortication (34 patients) or extrapleural pneumonectomy (4 patients). Chemotherapy solutions, primarily cisplatin, were heated between 40-42 degrees Celsius for administration during surgeries. The median patient age was 68 years, and males constituted 76.3% of the cohort. The median follow-up was 19 months. The most common histological subtype was epithelioid (78.9%).<br /><br />Key findings included a median operative time of approximately 8 hours and 40 minutes, with a median hospital stay of 8 days. Grade III complications were noted in 26.3% of cases, but there were no 30-day or 90-day mortalities reported. The one-year survival rate stood at 80%, with a median overall survival of 19 months. Importantly, patients receiving adjuvant chemotherapy demonstrated significantly higher survival rates, with a median survival of 93 months compared to 16 months for those who did not receive it.<br /><br />The study concludes that HITHOC with cytoreductive surgery is a feasible and effective approach with good short-term outcomes for malignant mesothelioma management. Long-term survival improvements, particularly when paired with adjuvant chemotherapy, highlight the potential benefits of a multidisciplinary treatment approach. However, definitive assessment of survival benefits was limited due to the rarity of the disease and lack of direct comparison groups.

Asset Subtitle

Yota Suzuki

Meta Tag

Speaker Yota Suzuki

Topic Mesothelioma, Thymoma, and Other Thoracic Tumors

Keywords

Hyperthermic Intrathoracic Chemoperfusion

HITHOC

cytoreductive surgery

malignant mesothelioma

University of Pittsburgh Medical Center

surgical outcomes

survival rates

adjuvant chemotherapy

epithelioid subtype

multidisciplinary treatment