2024 World Conference on Lung Cancer (WCLC) - ePosters-EP.14C.03 Long-Term Outcomes of Unresectable Tracheobronchial Tumors Treated with Radiotherapy- Analysis from a Tertiary Cancer Centre

EP.14C.03 Long-Term Outcomes of Unresectable Tracheobronchial Tumors Treated with Radiotherapy- Analysis from a Tertiary Cancer Centre

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This study from Tata Memorial Hospital, India, examines the long-term outcomes of unresectable tracheobronchial (TB) tumors treated with radiotherapy. These types of tumors are rare thoracic malignancies, and radical radiation therapy is typically employed for cases where surgical resection is not feasible or when cancer margins remain positive after surgery. The research retrospectively analyzed data from 2012 to 2024 for TB tumors treated at the hospital, focusing on clinicopathological variables and survival rates calculated through the Kaplan-Meier method. <br /><br />In this analysis, 28 patients were treated, with a median age of 44 and a slight male predominance. Debulking surgery was performed on 18 patients, with stent placement in three cases. Twenty-two patients received definitive radiotherapy, while six underwent adjuvant radiotherapy due to margin issues. The median radiation dose was 60 Gy, with additional conformal RT and intraluminal brachytherapy boosts applied in specific cases. All patients undergoing radical RT also received concurrent chemotherapy.<br /><br />The median follow-up period was 29 months. Of the patients, 23 were alive at the study's data cut-off. Disease relapse occurred in 10 patients, and local and distant relapses were noted. Median progression-free survival (PFS) was 26 months, with a 3-year PFS of 65%. Overall survival (OS) was 42 months, with a 3-year OS rate of 87%. Toxicity was observed, with acute Grade 2 toxicity in 14% of patients and late Grade 2 in 25%, leading to conditions such as cough and dysphagia. Severe complications included tracheo-esophageal fistula and tracheal stenosis.<br /><br />The study concludes that radical chemoradiotherapy (CTRT) provides effective local control and significant overall survival in treating unresectable tracheobronchial tumors, though late toxicity remains a concern, necessitating ongoing interventions.

Asset Subtitle

Anil Tibdewal

Meta Tag

Speaker Anil Tibdewal

Topic Mesothelioma, Thymoma, and Other Thoracic Tumors

Keywords

unresectable tracheobronchial tumors

radiotherapy

Tata Memorial Hospital

thoracic malignancies

Kaplan-Meier method

concurrent chemotherapy

progression-free survival

overall survival

toxicity

chemoradiotherapy