2024 World Conference on Lung Cancer (WCLC) - ePosters-EP.15B.04 High-Fiber Intake Predicts Overall Survival in Lung Cancer Patients

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This study, initiated by researchers from Oncoclínicas&Co - Medica Scientia Innovation Research in Brazil and several other institutions, focused on the impact of dietary fiber intake on the overall survival of lung cancer patients. Despite advancements in targeted therapies and checkpoint inhibitors for treating lung cancer, patient responses often remain unsatisfactory. The intestinal microbiome, influenced by factors like dietary fiber intake, has shown to modulate treatment outcomes.<br /><br />A cohort study of lung cancer patients was conducted at a private cancer center in Rio de Janeiro, Brazil, between January and December 2019. The study involved 50 patients, primarily elderly and diagnosed with advanced-stage non-small cell lung cancer (NSCLC). Most of them (90%) received chemotherapy and/or immunotherapy as first-line treatment.<br /><br />The analysis involved dietary assessments through 24-hour recalls to measure fiber intake, followed by Kaplan-Meier survival analyses. Results demonstrated that patients consuming over 19.05 grams of dietary fiber per day had a significantly higher median overall survival of 56.5 months compared to 33.9 months for those with lower fiber intake.<br /><br />Nearly 76% of the patients exhibited nutritional risk, with many showing signs of malnutrition and weight loss, signaling the importance of nutritional support. The study concluded that adequate dietary fiber intake at the time of lung cancer diagnosis could be a predictor of better treatment outcomes and overall survival. Incorporating nutritional interventions into patient care is advocated to potentially enhance clinical outcomes through the modulation of the intestinal microbiome and antitumor immunity. This simple, accessible approach can be personalized and integrated into the journey of lung cancer treatment, advocating for a shift towards better dietary practices.

Asset Subtitle

Imanuely Borchardt

Meta Tag

Speaker Imanuely Borchardt

Topic Multidisciplinary Care: Nursing, Allied Health and Palliative Care

Keywords

lung cancer

dietary fiber

overall survival

intestinal microbiome

nutritional interventions

non-small cell lung cancer

chemotherapy

immunotherapy

Kaplan-Meier survival analysis

treatment outcomes