PP01.18: Genome-Wide CRISPR/Cas9 Screens Utilizing an Endogenous Reporter for ASCL1 Abundance Identifies Mechanisms of ASCL1 Protein Stability
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Pdf Summary
Asset Subtitle
Keita Masuzawa
Keywords
ASCL1
small cell lung cancer
SCLC
protein stability
CRISPR/Cas9
HUWE1
E3 ubiquitin ligase
polyubiquitination
therapeutic target
c-terminal degron
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