Best Practices and Research Advances in Thoracic Oncology: A Regional Series LATAM Course 1: Liquid Biopsy in Lung Cancer-Common Problems of Liquid Biopsy: The Pathologist Point of View

Common Problems of Liquid Biopsy: The Pathologist Point of View

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Video Summary

In this detailed presentation on liquid biopsy in lung cancer, the speaker highlights common challenges from a pathologist’s perspective and its significant clinical potential. Liquid biopsies, often utilizing blood samples, identify circulating tumor DNA/RNA and offer non-invasive, rapid insights into tumor heterogeneity, though with cost hurdles and risk of false negatives. In contrast, tissue biopsies provide valuable histopathological data but require invasive procedures. Implementation in Latin America faces logistical, cost, and expertise challenges, with molecular testing centralized in major cities. The talk emphasizes the importance of adhering to guidelines, ensuring proper sample collection, and quality control. Moreover, structuring clear, informative reports and facilitating access to tumor boards is crucial for effective treatment decisions, particularly given regional disparities in resources and expertise. Collaboration across specialties and regions is essential to optimizing outcomes for lung cancer patients.

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Mercedes Liliana Dalurzo, MD

Keywords

liquid biopsy

lung cancer

tumor heterogeneity

pathologist perspective

Latin America challenges