Best Practices and Research Advances in Thoracic Oncology: A Regional Series LATAM Course 3: Driver Alterations in Lung Cancer-CNS Metastasis in Driver Alterations: Clinical Case

CNS Metastasis in Driver Alterations: Clinical Case

Video Transcription

Video Summary

A 63-year-old male with a history of lung adenocarcinoma developed brain and probable leptomeningeal metastases. Imaging revealed multiple lesions, but CSF tests were negative. The patient received full-brain radiotherapy and alectinib therapy, achieving a complete intracranial and nodal response and limited bone activity after 27 months. Lung cancer patients with brain metastases face reduced survival and quality of life, as traditional chemotherapies struggle to cross the blood-brain barrier. Newer TKIs, like osimertinib and alectinib, effectively penetrate the CNS, improving outcomes for patients with oncogene-driven brain metastases.

Asset Subtitle

Monica Castro, MD

Keywords

lung adenocarcinoma

brain metastases

alectinib therapy

TKIs

blood-brain barrier