Best Practices and Research Advances in Thoracic Oncology: A Regional Series SE Asia Course 3: Driver Alterations in Lung Cancer-Brain Metastasis in Driver Alterations with Clinical Case

Brain Metastasis in Driver Alterations with Clinical Case

Video Transcription

Video Summary

Dr. Puneet Iyengar discusses the management of brain metastases in non-small cell lung cancer patients with targetable molecular alterations. The focus is on a clinical case with an EGFR-mutant tumor, exploring the decision-making process regarding the use of osemirinib in conjunction with SRS (stereotactic radiosurgery). Current guidelines suggest using CNS active TKIs with a potential delay in SRS until disease progression. Studies indicate that combining SRS with TKIs may reduce CNS progression but does not significantly impact overall survival. Challenges include determining the precise timing and use of SRS, considering factors like lesion size and systemic disease control. Ongoing trials, like ICON-RT, aim to clarify the timing and sequence of SRS and TKIs for optimal brain metastasis management. The evolving strategies emphasize personalized approaches based on specific patient conditions and characteristics to improve outcomes.

Asset Subtitle

Puneeth Iyengar, MD, PhD

Keywords

brain metastases

non-small cell lung cancer

EGFR-mutant tumor

stereotactic radiosurgery

CNS active TKIs

personalized approaches