Cased-Based Controversies in Locally Advanced NSCLC: A Radiation Oncology Update Webinar-Case-based Controversies in Locally Advanced NSCLC: A Radiation Oncology Update

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Video Summary

The ISLC webinar focused on controversies and updates in the treatment of locally advanced non-small cell lung cancer (NSCLC), particularly within radiation oncology. Moderated by Dr. Stephen Chun from MD Anderson Cancer Center, the webinar included presentations by Dr. Andrea Filippi and Dr. Pamela Sampson. Dr. Filippi discussed recent clinical trials, such as Pacific II and Checkmate 73L, which explored combining immunotherapy with chemotherapy in treating stage III NSCLC. These trials were negative, indicating that concurrent immunotherapy with chemoradiation may not be effective. Ongoing trials and molecular data updates highlight promising avenues and significant molecular responses. Dr. Sampson addressed the challenges of re-irradiation therapy in NSCLC for recurrent early-stage disease. She outlined decision-making frameworks, patient selection for re-treatment, and dosimetric considerations, emphasizing the growing need to incorporate advanced imaging and plan evaluation strategies to ensure safety. The presentations underscored the complexity of treating locally advanced NSCLC, reflecting advances in medical technology and emerging treatment modalities, such as targeted therapies and the integration of immunotherapy. Panelists also discussed pertinent case studies and addressed challenging scenarios like in-field recurrences and management options after perioperative therapies. The webinar offered education on current controversies and strategies that aim to better clinical outcomes, illustrating the dynamic and rapidly evolving landscape of lung cancer management.

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Keywords

locally advanced NSCLC

radiation oncology

immunotherapy

chemotherapy

clinical trials

re-irradiation therapy

molecular responses

targeted therapies

advanced imaging

lung cancer management