State-of-the-Art in Combination Immuno/Radiotherapy for Non-Small Cell Lung Cancer-State-of-the-Art in Combination Immuno_Radiotherapy for Non-Small Cell Lung Cancer

Video Transcription

Video Summary

Today's seminar focused on the combination of immunotherapy and radiotherapy for non-small cell lung cancer. The presenters discussed the current state of immunotherapy and the need to improve outcomes, as well as the potential benefits of combining immunotherapy with radiotherapy. They explained that radiation treatment can have an immunogenic effect and upregulate tumor cell checkpoints. They also discussed the concept of the abscopal effect, where localized radiation can have off-target effects on distant tumor sites. However, they noted that abscopal responses are rare and unpredictable. The presenters emphasized the importance of sequencing and optimal dose fractionation for effective combination therapy. They also highlighted the need to consider tumor site and target volume when planning radiotherapy. In terms of safety, the presenters discussed the potential for increased toxicity when combining immunotherapy and radiotherapy, particularly in patients with a history of immune-related adverse events or brain metastases. They also discussed the challenges of combining immunotherapy with other treatments such as anti-angiogenics. Despite these challenges, the presenters expressed optimism about the potential for combination therapy to improve outcomes for patients with non-small cell lung cancer. They mentioned ongoing trials and future directions for research, including investigating the role of hypoxia modification, treating brain metastases, and exploring neoadjuvant immunotherapy. Overall, the presenters highlighted the complex nature of combination therapy and the need for further research to optimize treatment strategies.

Keywords

immunotherapy

radiotherapy

non-small cell lung cancer

combination therapy

abscopal effect

dose fractionation

sequencing

toxicity

brain metastases

anti-angiogenics

research