WCLC 2025 - Posters & ePosters-EP.01.06 Clinical Characteristics, Molecular Profile and Survival Outcomes in Young Lung Cancer Patients From Western India

EP.01.06 Clinical Characteristics, Molecular Profile and Survival Outcomes in Young Lung Cancer Patients From Western India

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This retrospective study analyzed clinical characteristics, molecular profiles, and survival outcomes of young lung cancer patients (≤50 years) from Western India, encompassing 297 individuals (13% of total lung cancer cases) diagnosed between March 2018 and September 2024. The median age was 45 years with a slight male predominance (M:F ratio 1.14:1). Smoking history was reported in 32.2% of males and 13.7% of females. Most patients (90.9%) had non-small cell lung cancer (NSCLC), primarily adenocarcinoma (84.1%). Stage IV disease was common (77.8%), with frequent metastases to bone (58%), brain (32.4%), liver (21.2%), and lymph nodes (22.5%).<br /><br />Molecular testing was performed in 66.3% (197/297), revealing mutation positivity in 55.3%. Key alterations included EGFR mutations, ALK rearrangements (12.7% in young vs. 5.6% overall), and ROS1 rearrangements. PD-L1 expression ≥1% was observed in a subset. Comprehensive and short next-generation sequencing (NGS) panels were used, yielding detection rates of various mutations including tumor mutation burden (TMB).<br /><br />Survival outcomes showed a median overall survival (mOS) of 38.1 months for the cohort. Females had better mOS (57.2 months) compared to males (32.9 months). Importantly, patients receiving targeted therapies had significantly improved mOS (49 months) versus those who did not (17.2 months). Median follow-up was 21.3 months.<br /><br />The study highlights that young lung cancer patients in Western India display distinct disease biology with a high prevalence of actionable molecular alterations, emphasizing the critical role of early molecular profiling and personalized treatment. These findings call for tailored diagnostic and therapeutic strategies to improve outcomes in this unique and challenging patient population.

Asset Subtitle

Udip Maheshwari

Meta Tag

Speaker Udip Maheshwari

Topic Risk Factors, Risk Reduction & Tobacco Control

Keywords

young lung cancer

Western India

non-small cell lung cancer

adenocarcinoma

EGFR mutations

ALK rearrangements

ROS1 rearrangements

targeted therapies

molecular profiling

survival outcomes