WCLC 2025 - Posters & ePosters-EP.01.28 Changes in Respiratory Function in a Patient Undergoing Two Lung Resections

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This study investigated changes in respiratory function in 35 patients who underwent two lung resections between January 2010 and December 2024, assessing their pulmonary function one year after the second surgery. The aim was to compare actual postoperative pulmonary function with predicted values based on the volume of lung tissue resected. Predictions accounted for partial resections (3% function decrease) and segmentectomies or lobectomies calculated by the number of subsegments removed.<br /><br />Results showed that in approximately 90% of cases, actual respiratory function exceeded predicted values across all measured parameters. The degree of discrepancy was greatest in patients undergoing two lobectomies, followed by those with one lobectomy plus limited resection, and lowest in those with two limited resections. Statistical analysis revealed moderate to strong correlations (Pearson coefficients ≥ 0.6, p < 0.01) between predicted and actual pulmonary functions.<br /><br />Comparing these findings with previous studies on single lung resections, the discrepancy between actual and predicted postoperative FEV1 values tends to increase with the number of resected lung segments, especially involving the lower lobes. This study extends these observations to patients with repeated resections on both lungs, indicating that larger resection volumes are associated with better-than-predicted compensatory lung expansion and functional recovery.<br /><br />The authors highlight the need for further research with larger cohorts to refine predictive models of postoperative pulmonary function after multiple lung surgeries. The study underscores the importance of considering compensatory mechanisms when planning surgery and counseling patients about expected respiratory outcomes.<br /><br />Acknowledgements were given to supervising physicians and collaborators who contributed to study guidance and data analysis.

Asset Subtitle

Nanami Hiraiwa

Meta Tag

Speaker Nanami Hiraiwa

Topic Risk Factors, Risk Reduction & Tobacco Control

Keywords

respiratory function

lung resection

pulmonary function

lobectomy

segmentectomy

postoperative prediction

lung volume resected

FEV1

compensatory lung expansion

functional recovery