WCLC 2025 - Posters & ePosters-EP.01.29 Association of the Cholesterol-Modified Prognostic Nutritional Index With the Survival After Lung Resection for Elderly Patients With NSCLC

EP.01.29 Association of the Cholesterol-Modified Prognostic Nutritional Index With the Survival After Lung Resection for Elderly Patients With NSCLC

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This study by Yuuki Matsui from the NHO Osaka National Hospital investigates the prognostic value of the cholesterol-modified prognostic nutritional index (CPNI) in elderly patients undergoing lung resection for non-small cell lung cancer (NSCLC). Nutritional and inflammatory markers such as the traditional prognostic nutritional index (PNI), neutrophil-lymphocyte ratio (NLR), C-reactive protein-albumin ratio (CAR), and controlling nutritional status (CONUT) scores are established prognostic factors in NSCLC. The CPNI, a novel nutritional assessment that incorporates cholesterol levels into the PNI, has previously demonstrated superior predictive accuracy for overall survival (OS) in breast and liver cancers.<br /><br />The study aims to validate CPNI’s effectiveness compared to existing nutritional indicators in predicting OS in elderly NSCLC patients. Statistical analyses including t-tests, chi-square tests, Kaplan-Meier survival curves, log-rank tests, and Cox proportional hazards models were used to evaluate survival data.<br /><br />Findings highlight that hypoalbuminemia and low lymphocyte counts correlate with poor immune status, while serum cholesterol levels have complex associations: elevated cholesterol metabolism can reduce lung cancer risk, but high cholesterol levels may also promote tumor aggressiveness and worse outcomes. Notably, a high preoperative CPNI was identified as a potential risk factor influencing survival after lung resection.<br /><br />In conclusion, the study suggests that CPNI might serve as a superior tool for assessing nutritional status and prognosticating survival in elderly NSCLC patients undergoing surgery compared to traditional markers like PNI, NLR, CAR, and CONUT. Incorporating CPNI into clinical practice could enhance decision-making and optimize treatment strategies for this patient population.

Asset Subtitle

Yuuki Matsui

Meta Tag

Speaker Yuuki Matsui

Topic Risk Factors, Risk Reduction & Tobacco Control

Keywords

cholesterol-modified prognostic nutritional index

CPNI

non-small cell lung cancer

NSCLC

elderly patients

lung resection

prognostic nutritional index

PNI

neutrophil-lymphocyte ratio

NLR