WCLC 2025 - Posters & ePosters-EP.02.06 Natural Multiple Serine Synthase Inhibitors Modulate Tumor Microenvironment Polarization and Inhibit the Growth of Lung Cancer

EP.02.06 Natural Multiple Serine Synthase Inhibitors Modulate Tumor Microenvironment Polarization and Inhibit the Growth of Lung Cancer

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This study explores the anti-cancer potential of exosomes derived from the natural Chinese herbal medicine Pinellia ternata, focusing on their effects on lung cancer cells and the tumor microenvironment. Lung cancer cells have high metabolic demands and rely heavily on amino acids like serine and glycine. Pinellia ternata is known for its ability to improve cellular lipid metabolism, regulate immunity, and exhibit anti-tumor effects. The researchers found that Pinellia exosomes inhibit the expression of genes involved in serine synthesis, which modulates the tumor microenvironment by affecting both lung cancer cells and macrophages. This dual action suppresses lung cancer growth. The findings indicate that natural multiple serine synthase inhibitors from Pinellia can alter tumor microenvironment polarization, leading to inhibited lung tumor progression. This approach combines traditional Chinese herbal medicine with modern nanotechnology, offering a novel therapeutic strategy against lung cancer. The study highlights the potential of using plant-derived nanovesicles as targeted antineoplastic agents, aligning with recent advancements in biochemical hallmark-targeting nanotherapies. References supporting this work include recent research on antineoplastic nanotherapeutics and plant-derived nanovesicles for therapeutic applications. Overall, this research provides a promising and innovative pathway for lung cancer treatment by leveraging natural herbal medicine’s bioactive nanostructures to impact cancer metabolism and immune cell function within tumors.

Asset Subtitle

Menghan Liu

Meta Tag

Speaker Menghan Liu

Topic Tumor Biology – Preclinical Biology

Keywords

Pinellia ternata

exosomes

lung cancer

tumor microenvironment

serine synthesis inhibition

macrophage modulation

anti-cancer potential

plant-derived nanovesicles

Chinese herbal medicine

nanotherapy