WCLC 2025 - Posters & ePosters-EP.04.04 A Relative Perspective on Whether Risk-Based Lung Screening Eligibility Prioritize People With Higher Competing Mortality

EP.04.04 A Relative Perspective on Whether Risk-Based Lung Screening Eligibility Prioritize People With Higher Competing Mortality

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This study evaluates whether risk-based lung cancer screening effectively prioritizes individuals who not only have a high risk of lung cancer death but also considers their competing mortality risks from other causes. Using data from 53,152 participants in the National Lung Screening Trial (NLST) and 400,935 smokers from three cohorts within the Lung Cancer Cohort Consortium (LC3), the researchers assessed 6-year lung cancer risk via the PLCOm2012 model. They specifically analyzed the ratio of deaths from other causes relative to lung cancer deaths across different lung cancer risk levels.<br /><br />Results showed that this ratio decreases as lung cancer risk increases. In the NLST cohort, ratios of competing to lung cancer deaths across risk quintiles from lowest to highest were 5.8, 4.5, 3.1, 2.6, and 2.3, respectively. This inverse relationship was consistent in both NLST and LC3 populations, indicating that while individuals with higher lung cancer risk also tend to have elevated competing mortality rates, the proportion of competing deaths relative to lung cancer deaths declines with increasing lung cancer risk.<br /><br />The findings suggest that risk-based screening models successfully prioritize individuals more likely to die of lung cancer rather than from other competing causes, supporting the efficiency of such models over categorical criteria. In summary, risk-based lung cancer screening eligibility tends to focus on those with a relatively greater chance of lung cancer mortality, despite the presence of other health risks, potentially optimizing screening benefits.

Asset Subtitle

Xiaoshuang Feng

Meta Tag

Speaker Xiaoshuang Feng

Topic Screening and Early Detection

Keywords

lung cancer screening

risk-based screening

competing mortality risks

National Lung Screening Trial (NLST)

Lung Cancer Cohort Consortium (LC3)

PLCOm2012 model

lung cancer death risk

mortality ratio

screening eligibility

risk prioritization