WCLC 2025 - Posters & ePosters-EP.04.19 Radiologic Characteristicsof Solitary Pulmonary Capillary Hemangioma

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This work investigates the radiologic characteristics of solitary pulmonary capillary hemangioma (SPCH), a rare benign lung lesion first reported in 2006, comparing it to lung adenocarcinoma (LC) due to their overlapping imaging features. SPCH appears on CT scans as nonsolid, part-solid, or solid nodules and often mimics adenocarcinoma, leading to diagnostic challenges.<br /><br />The study included 44 SPCH cases and 352 matched lung adenocarcinoma cases. Key findings include:<br /><br />- SPCH lesions more frequently involve the lower lobes compared to adenocarcinoma.<br />- In nonsolid and part-solid nodules, SPCH shares many imaging features with adenocarcinoma, such as size and margin appearance; however, SPCH often has an unclear margin.<br />- Part-solid SPCH nodules demonstrate higher rates of air bronchogram presence but a lack of lobulation, spiculation, and pleural retraction signs common in lung adenocarcinoma.<br />- Solid SPCH nodules are also more prevalent in lower lobes, show more air bronchograms, but lack typical adenocarcinoma features such as spiculation and pleural retraction.<br />- Unique radiologic features of SPCH include central branching or tubular lucency and perivascular lucency, corresponding histologically to irregular dilated bronchioles with capillary proliferation and dilated pulmonary veins adjacent to spared capillary areas.<br /><br />Histopathologically, SPCH lesions are ill-defined nodules composed of densely proliferative thin-walled capillaries infiltrating alveolar septa without cellular atypia or mitotic activity, and immunohistochemistry confirms endothelial markers positivity.<br /><br />The study emphasizes that while SPCH radiologically resembles lung adenocarcinoma, distinguishing features—such as lower lobe predominance, unclear margins, presence of air bronchograms, and absence of spiculation/lobulation—can aid diagnosis. Recognizing SPCH is critical to avoid overtreatment of benign lesions mistaken for cancer.<br /><br />In summary, this research provides valuable CT imaging criteria and pathological correlation for SPCH, enhancing diagnostic accuracy and guiding clinical management distinct from lung adenocarcinoma.

Asset Subtitle

Yeqing Zhu

Meta Tag

Speaker Yeqing Zhu

Topic Screening and Early Detection

Keywords

solitary pulmonary capillary hemangioma

SPCH

lung adenocarcinoma

CT imaging

nonsolid nodules

part-solid nodules

solid nodules

air bronchogram

lower lobe predominance

radiologic differentiation