WCLC 2025 - Posters & ePosters-EP.09.16 Airway Stenting for the Treatment of Airway Stenosis in Advanced Lung Cancer; a Study of 20 Patients With Advanced Lung Cancer

EP.09.16 Airway Stenting for the Treatment of Airway Stenosis in Advanced Lung Cancer; a Study of 20 Patients With Advanced Lung Cancer

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This study evaluated the outcomes of airway stenting in 20 patients with advanced lung cancer complicated by central airway stenosis, treated at Tokushima University between 2005 and 2024. Airway stenosis in advanced lung cancer often causes severe symptoms, including dyspnea and hemoptysis, and can lead to life-threatening emergencies. The study aimed to assess short- and long-term effects of stenting on symptom relief, functional status, complications, and survival.<br /><br />Patients were mostly male (95%) with a mean age of about 63 years, primarily presenting with dyspnea (85%). Stenosis locations included the main bronchus (60%) and the carina (40%). Most had stage III or IV lung cancer and had prior systemic therapy (90%). Stenting was performed under general anesthesia using metal or silicone stents. Flexible bronchoscopy was the main technique used.<br /><br />Post-stenting, significant improvement was seen in performance status (PS) and dyspnea measured by the modified Medical Research Council (MRC) scale, with about 55% improvement rates for both. Five patients with severe respiratory compromise requiring mechanical ventilation or ECMO were successfully weaned shortly after stenting. Acute complications were minimal; sputum retention occurred in 20%, stent deviation in 5%, and one case of granulation required stent removal later.<br /><br />Median survival after stenting was approximately 199 days. Patients receiving additional post-stent cancer therapy showed a trend toward longer median survival (418 days) compared to those without further therapy (88 days), though this difference was not statistically significant.<br /><br />The study concludes that airway stenting offers effective symptom relief and functional improvement in advanced lung cancer with airway obstruction. It facilitates respiratory stabilization even in critically ill patients. Future stent selection should consider ongoing cancer treatments and potential complications, emphasizing individualized patient management. Overall, airway stenting may serve as a crucial intervention bridging patients to further therapy and improving quality of life.

Asset Subtitle

Ayaka Tsuji

Meta Tag

Speaker Ayaka Tsuji

Topic Metastatic Non-small Cell Lung Cancer – Local Therapies

Keywords

airway stenting

advanced lung cancer

central airway stenosis

dyspnea

hemoptysis

bronchoscopy

performance status improvement

respiratory stabilization

stent complications

survival outcomes