WCLC 2025 - Posters & ePosters-EP.14.06 Survival Analysis in Malignant Pleural Mesothelioma

Pdf Summary

This retrospective single-center study from Turkey analyzed survival outcomes in 44 patients diagnosed with malignant pleural mesothelioma (MPM) between 2015 and 2025. The study aimed to evaluate the impact on overall survival (OS) of surgical intervention (yes vs. no), surgical type (pleurectomy/decortication [P/D] vs. extrapleural pneumonectomy [EPP]), and radiotherapy (RT) administration.<br /><br />Key findings showed a median OS of 27.9 months for all patients. Surprisingly, patients who did not undergo surgery had a longer median OS (44.5 months) compared to those operated on (20.4 months), though this difference was not statistically significant (p=0.202). Among surgeries, P/D patients had a median OS of 27.9 months versus 20.4 months for EPP (p=0.468). Patients receiving RT had a median OS of 20.1 months compared to 28.3 months without RT (p=0.461).<br /><br />The unexpected longer survival in the non-operated group was attributed to their more timely and uninterrupted access to combined chemotherapy and immunotherapy, whereas surgical patients experienced treatment delays and irregular adjuvant therapy, potentially compromising outcomes. These findings underscore the importance of coordinated multidisciplinary care and seamless transitions between treatment phases in managing MPM.<br /><br />Overall, while surgical intervention remains a mainstay treatment, this study highlights that prompt systemic therapy without delays may be critical for improving survival in MPM patients. It suggests that optimizing treatment sequencing and minimizing delays in adjuvant therapy could enhance clinical outcomes. The authors emphasize the need for integrated multidisciplinary approaches for optimal management of this aggressive cancer.

Asset Subtitle

Heves Sürmeli

Meta Tag

Speaker Heves Sürmeli

Topic Mesothelioma, Thymoma, and Other Thoracic Tumors

Keywords

malignant pleural mesothelioma

survival outcomes

surgical intervention

pleurectomy/decortication

extrapleural pneumonectomy

radiotherapy

overall survival

chemotherapy

immunotherapy

multidisciplinary care