WCLC 2025 - Posters & ePosters-EP.17.24 Clinicopathological Features of Lung Cancer: A Study From a Tertiaryreferral Center in Georgia

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This retrospective observational study from the Caucasus Medical Centre, Georgia’s largest tertiary referral hospital, analyzed clinicopathological features of lung cancer in 270 patients diagnosed between January 2023 and February 2025. Inclusion criteria were pathologically confirmed primary lung cancer. Key data collected included demographics, smoking history, histology, cancer stage, metastasis sites, and molecular markers (EGFR, ALK, PD-L1).<br /><br />Patients had a median age of 67 years; the majority were male (86%) and Georgian ethnicity (91%). Most were smokers (67%). Histologically, non-small cell lung cancer (NSCLC) predominated (76%), mainly adenocarcinoma (52%) and squamous cell carcinoma (38%), with small-cell lung cancer (SCLC) accounting for 17%. At diagnosis, a large proportion had advanced disease: 67% stage IV with metastatic spread, commonly to bone and contralateral lung (29% and 28%, respectively).<br /><br />Molecular testing revealed EGFR mutations in 15.6% and ALK rearrangements in 10% of tested patients, more frequent among non-smokers and adenocarcinoma cases. PD-L1 expression was evaluated in 81 patients showing varied tumor proportion scores (TPS): 40% had TPS <1%, 32% TPS 1–49%, and 28% TPS ≥50%. No significant association was found between smoking status and PD-L1 status. Adenocarcinoma was significantly more common among non-smokers.<br /><br />The study highlights that lung cancer in Georgia is often diagnosed at an advanced stage, contributing to poor prognosis. Given the relative frequency of actionable mutations, the authors emphasize the necessity of routine molecular biomarker testing to inform targeted therapies. The findings support urgent implementation of national lung cancer screening programs, stronger tobacco control measures, expanded access to advanced imaging (PET-CT), molecular diagnostics, and precision oncology treatments to improve outcomes through earlier detection and personalized care.

Asset Subtitle

Anna Geguchadze

Meta Tag

Speaker Anna Geguchadze

Topic Global Health, Health Services, and Health Economics

Keywords

lung cancer

non-small cell lung cancer

small-cell lung cancer

EGFR mutations

ALK rearrangements

PD-L1 expression

adenocarcinoma

smoking history

advanced stage diagnosis

molecular biomarker testing