WCLC 2025 - Posters & ePosters-P1.07.23 Impact of Pulmonary Resection on Early Postoperative Cardiac Function

Pdf Summary

This study from Osaki Citizen Hospital explored the impact of pulmonary resection type—lobectomy versus segmentectomy—on early postoperative cardiac function in patients with non-small cell lung cancer (NSCLC). The investigation was prompted by recent findings from the JCOG0802 trial, which showed segmentectomy yielded better survival outcomes potentially due to fewer non-cancer-related deaths, possibly linked to differences in cardiac function after surgery.<br /><br />Fifty-three NSCLC patients without pre-existing cardiac disease who underwent surgical resection between January 2023 and March 2024 were included. Cardiac function was assessed before surgery, at 1 month, and at 6 months postoperatively using multiple parameters: left ventricular ejection fraction (LVEF) and plasma brain natriuretic peptide (BNP) for left heart function, and tricuspid annular plane systolic excursion (TAPSE), tricuspid annular systolic velocity (S’), and right ventricular fractional area change (RVFAC) for right heart function. Patient demographics, tumor location, clinical and pathological stages, surgical approach, and histology were also recorded.<br /><br />The patient groups (43 lobectomy, 10 segmentectomy) were generally comparable in age, gender, smoking status, tumor histology, and clinical stage. Results showed no significant differences between lobectomy and segmentectomy groups in early postoperative changes of either left or right ventricular function. Subgroup analysis of left-sided resections also found no meaningful differences. These findings suggest that the type of pulmonary resection (lobectomy vs. segmentectomy) does not cause early postoperative deterioration in cardiac function at rest.<br /><br />The study concludes that early postoperative cardiac function remains stable regardless of resection extent. However, it emphasizes the need for further evaluation of mid- and long-term cardiac outcomes, as well as assessments under exercise or stress conditions, to fully understand cardiac implications of lung cancer surgery.

Asset Subtitle

Toshimasa Okazaki

Meta Tag

Speaker Toshimasa Okazaki

Topic Early-Stage Non-small Cell Lung Cancer

Keywords

pulmonary resection

lobectomy

segmentectomy

non-small cell lung cancer

cardiac function

early postoperative

left ventricular ejection fraction

brain natriuretic peptide

right ventricular function

JCOG0802 trial