WCLC 2025 - Posters & ePosters-P1.07.32 Prognostic Value of Consolidation-To-Tumor Ratio in Stage IA Solid Predominant Non-Mucinous Adenocarcinoma

P1.07.32 Prognostic Value of Consolidation-To-Tumor Ratio in Stage IA Solid Predominant Non-Mucinous Adenocarcinoma

Pdf Summary

This study investigates the prognostic value of the consolidation-to-tumor ratio (CTR) in clinical stage IA solid predominant non-mucinous lung adenocarcinoma, focusing on tumors with CTR ≤0.5, where prognostic clarity is limited. Reviewing 2,789 patients who underwent curative resection between 2011 and 2021, researchers aimed to determine an optimal CTR cutoff within this range to enable better risk stratification.<br /><br />Using maximized log-rank statistics and propensity score matching, a CTR cutoff of 0.85 was identified as clinically significant for distinguishing prognosis. Patients with tumors having CTR values between 0.85 and 1 demonstrated significantly worse overall survival (OS) and freedom from recurrence (FFR) compared to those with CTR between 0.5 and 0.85. Additionally, higher frequencies of pathological risk factors—such as high-grade patterns, lymphovascular invasion, and nodal metastasis—were observed in the 0.85–1 group, with their survival and pathological profiles comparable to pure solid tumors (CTR = 1).<br /><br />The study acknowledges some limitations due to interreader variability in CTR measurement, which may impact the universal applicability of a fixed cutoff. Nonetheless, findings support the existence of a prognostic threshold within CTR ≤0.5 tumors, suggesting that tumors near a CTR of 1 (e.g., ~0.8) might require treatment and surveillance approaches similar to pure solid tumors.<br /><br />In conclusion, the CTR cutoff of 0.85 serves as an important prognostic marker in stage IA lung adenocarcinoma with CTR ≤0.5, enabling improved patient stratification and potentially guiding surgical and postoperative management to reflect tumor aggressiveness.

Asset Subtitle

Yura Ahn

Meta Tag

Speaker Yura Ahn

Topic Early-Stage Non-small Cell Lung Cancer

Keywords

consolidation-to-tumor ratio

CTR cutoff 0.85

stage IA lung adenocarcinoma

non-mucinous lung adenocarcinoma

prognostic marker

curative resection

overall survival

freedom from recurrence

pathological risk factors

tumor aggressiveness