WCLC 2025 - Posters & ePosters-P1.17.09 The Impact of Out-Of-Pocket Costs, Travel Distances and Clinic Visits on Quality of Life for Patients on TKIs

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This study from Princess Margaret Hospital in Toronto assessed how out-of-pocket costs, travel distances, and frequency of clinic visits affect quality of life in patients with metastatic EGFR-mutated non-small cell lung cancer (NSCLC) treated with oral tyrosine kinase inhibitors (TKIs). Using a survey of 175 patients starting first-line EGFR TKI treatment, researchers collected demographic data, expenses, travel distances, clinic visit numbers, and quality of life metrics via EQ-5D-5L health utilities.<br /><br />The cohort had a median age of 65, predominantly female (63%), mostly Asian (73%), and largely never-smokers (71%). About 31% had low household incomes (< CAD 30,000), and 24% had a job change post-diagnosis. Importantly, 30% incurred substantial out-of-pocket expenses (> 80 CAD) related to cancer care. <br /><br />Key findings included that higher out-of-pocket costs and more frequent clinic visits were significantly associated with lower overall health utility scores and worsened components such as anxiety/depression, mobility, self-care, usual activities, and pain/discomfort. Travel distance did not correlate with overall health utility but was related to pain and discomfort levels.<br /><br />The results emphasize that financial burdens and healthcare access (through clinic visits) negatively impact patients' quality of life and functional status. The study highlights the vital role nurses can play in identifying and mitigating these barriers via assessments and coordinated care, including telehealth. The researchers advocate for developing standardized tools and support mechanisms involving nursing, social work, and pharmacy to better address these obstacles for TKI-treated NSCLC patients.<br /><br />In conclusion, the study underscores the multifaceted impact of logistical and financial barriers on quality of life in metastatic EGFR-mutated NSCLC patients on TKIs within a universal healthcare system. Targeted interventions led by healthcare professionals are needed to improve patient outcomes by alleviating these burdens.

Asset Subtitle

Kezia Rafique

Meta Tag

Speaker Kezia Rafique

Topic Global Health, Health Services, and Health Economics

Keywords

metastatic EGFR-mutated NSCLC

tyrosine kinase inhibitors

out-of-pocket costs

clinic visit frequency

quality of life

EQ-5D-5L health utilities

financial burden

travel distance

nursing interventions

universal healthcare system