WCLC 2025 - Posters & ePosters-P2.15 .12 Non-Pharmacological Dermatologic Care for the Prevention and Management of Immune-Related Skin Toxicities in Patients With Lung Cancer

P2.15 .12 Non-Pharmacological Dermatologic Care for the Prevention and Management of Immune-Related Skin Toxicities in Patients With Lung Cancer

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This study evaluates the effectiveness of non-pharmacological dermatologic care in preventing and managing immune-related skin toxicities (irAEs) in lung cancer patients undergoing immunotherapy. Immune checkpoint inhibitors, while improving cancer outcomes, can cause irAEs, with dermatologic issues such as pruritus and dryness affecting about 40% of patients. Early detection and management of these skin toxicities are essential to maintain patients' quality of life.<br /><br />The single-center, phase IV randomized trial involved 58 lung cancer patients divided into intervention (31 patients) and control (27 patients) groups. Both groups used cleansing and moisturizing products; however, the intervention arm received formulations containing Niacinamide, Vitreosilla Filiformis, and shea butter, whereas the control group used products with argan oil and coconut butter. Data were collected at baseline and at three subsequent visits spaced eight weeks apart, utilizing the Itch Severity Scale and the Dermatology Life Quality Index.<br /><br />Results demonstrated a significant reduction in pruritus incidence among the intervention group. While pruritus incidence in the control group rose from nearly 0% to 80% by the third visit, the intervention group's pruritus stayed below 25% consistently. This suggests that the specific moisturizing agents helped prevent symptom progression and improve skin condition. Additional questionnaires revealed the importance of routine soap and cream use, sunscreen application, and the minimal need for medication due to skin toxicity in the intervention group.<br /><br />The study underscores the clinical significance of incorporating structured skin care regimens into standard oncological care to reduce dermatologic irAEs. Implementation of an immunotherapy nursing program aided early detection and management of irAEs, enhancing patient satisfaction and reducing waiting times for specialist visits. Future research should continue optimizing supportive care to improve patients' quality of life during immunotherapy.

Asset Subtitle

Jorgina Serra López

Meta Tag

Speaker Jorgina Serra López

Topic Multidisciplinary Care: Nursing, Allied Health and Palliative Care

Keywords

non-pharmacological dermatologic care

immune-related adverse events

irAEs

lung cancer

immunotherapy

immune checkpoint inhibitors

pruritus prevention

skin toxicity management

Niacinamide moisturizer

quality of life