WCLC 2025 - Posters & ePosters-P2.15 .21 Feasibility and Preliminary Efficacy of Multimodal Prehabilitation in Patients With NSCLC Receiving Neoadjuvant Therapy

P2.15 .21 Feasibility and Preliminary Efficacy of Multimodal Prehabilitation in Patients With NSCLC Receiving Neoadjuvant Therapy

Back to course

Pdf Summary

This prospective cohort study evaluated the feasibility and preliminary efficacy of a supervised multimodal prehabilitation program in patients with non-small cell lung cancer (NSCLC) undergoing neoadjuvant therapy (NAT) prior to surgery. NAT can cause declines in cardiopulmonary fitness (CRF) and lung function, so the intervention aimed to prevent such deterioration.<br /><br />The prehabilitation program included twice-weekly supervised exercise sessions combining endurance and resistance training, individualized dietary assessment and supplementation, and psychological support as needed. Of 24 patients screened, 20 were eligible, 14 enrolled, and 11 completed the program, yielding a 70% recruitment and high retention rate. Median adherence was 67% of prescribed sessions, with no adverse events related to the intervention.<br /><br />Assessments before and after NAT measured peak oxygen consumption (VO2peak), CPET parameters, and lung function. Results showed a non-significant decline in VO2peak and oxygen pulse after NAT, accompanied by a significant drop in hemoglobin levels. Maximal workload remained stable, lung volumes (FEV1, FVC) were unchanged, but the lung diffusion capacity (DLCO) significantly decreased.<br /><br />In conclusion, multimodal prehabilitation for NSCLC patients receiving NAT is feasible and safe, with good patient acceptance and adherence. However, it did not prevent the decline in CRF observed during treatment. These findings highlight the challenge of preserving cardiopulmonary function in this population and suggest further research is needed to optimize prehabilitation strategies for improving fitness and clinical outcomes.

Asset Subtitle

Raquel Sebio-Garcia

Meta Tag

Speaker Raquel Sebio-Garcia

Topic Multidisciplinary Care: Nursing, Allied Health and Palliative Care

Keywords

non-small cell lung cancer

neoadjuvant therapy

prehabilitation program

cardiopulmonary fitness

exercise training

dietary supplementation

psychological support

lung function

VO2peak

lung diffusion capacity