WCLC 2025 - Posters & ePosters-P3.01.05 Decoding the Sleep Enigma: A Proteomic Mediation Analysis Linking Healthy Sleep Patterns to Lung Cancer Risk

P3.01.05 Decoding the Sleep Enigma: A Proteomic Mediation Analysis Linking Healthy Sleep Patterns to Lung Cancer Risk

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This study, titled "Decoding the Sleep Enigma: A Proteomic Mediation Analysis Linking Healthy Sleep Patterns to Lung Cancer Risk," investigates the biological relationship between sleep quality and lung cancer incidence. Conducted by researchers at the Guangzhou Institute of Respiratory Health and affiliated institutions in China, the study aims to uncover how healthy sleep patterns may influence lung cancer risk through specific protein mediators, ultimately developing a biomarker panel related to sleep.<br /><br />Using a comprehensive methodological approach, the researchers identified protein signatures associated with healthy sleep scores that significantly lowered lung cancer risk. Key findings include a hazard ratio (HR) of 0.864 (p=0.001) for lung cancer and non-small cell lung cancer (NSCLC) among individuals with better sleep protein signatures, indicating a protective effect. Moreover, higher healthy sleep scores correlated with further risk reduction: an HR of 0.584 for score 3 and 0.514 for score 4, both statistically significant. These trends were consistent across NSCLC and lung adenocarcinoma (LUAD) subtypes.<br /><br />The mediation analysis revealed 19 proteins that plausibly mediate the relationship between healthy sleep and lung cancer risk, each accounting for at least 10% of the mediation effect. Notably, the protein CXCL17 emerged as the strongest mediator, contributing 34.7% to the link between sleep and cancer risk.<br /><br />The authors highlight the enigmatic nature of the biological interplay between sleep and lung cancer and suggest that their findings offer valuable insights into potential cancer prevention strategies. They recommend future research to further explore the roles of CXCL17 and other proteins in lung cancer development and to consider incorporating these proteomic markers into clinical approaches targeting cancer prevention through healthy sleep promotion.

Asset Subtitle

Yi Feng

Meta Tag

Speaker Yi Feng

Topic Risk Factors, Risk Reduction & Tobacco Control

Keywords

Sleep Patterns

Lung Cancer Risk

Proteomic Mediation Analysis

Healthy Sleep Scores

Protein Biomarkers

CXCL17 Protein

Non-Small Cell Lung Cancer

Lung Adenocarcinoma

Cancer Prevention

Guangzhou Institute of Respiratory Health