WCLC 2025 - Posters & ePosters-P3.01.13 Lung Cancer Characteristics and Survival Among Smokers, Former Smokers, and Never Smokers Within an Australian Lung Cancer Registry

P3.01.13 Lung Cancer Characteristics and Survival Among Smokers, Former Smokers, and Never Smokers Within an Australian Lung Cancer Registry

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This retrospective cohort study analyzed lung cancer characteristics, management, and survival among 19,204 patients registered in the Victorian Lung Cancer Registry (Australia) from July 2011 to September 2024. Patients were categorized by smoking status into never smokers (13%), ex-smokers (52%), and current smokers (35%). Key findings showed that never smokers were more often female (70% vs. 44% overall), younger at diagnosis (median 70 years), had better socioeconomic status (61% advantaged), fewer comorbidities (62%), and better performance scores (ECOG 0 in 47%) compared to smokers and ex-smokers.<br /><br />Survival outcomes varied strongly by smoking status and lung cancer subtype. Among non-small cell lung cancer (NSCLC) patients (n=15,264), median survival was highest in never smokers at 3.3 years (95% CI 3.0-3.7), compared to 1.7 years for ex-smokers (HR 1.48, p<0.001) and 1.4 years for current smokers (HR 1.63, p<0.001). For small cell lung cancer (SCLC) patients (n=2,039), median survival was 1.2 years for never smokers, significantly longer than for ex-smokers (0.73 years, HR 1.62, p=0.005) and current smokers (0.78 years, HR 1.46, p=0.027).<br /><br />The study used statistical analyses including Kruskal-Wallis, Fisher’s exact, Pearson’s Chi-square, Kaplan-Meier survival estimates, and multivariable Cox regression to identify smoking status as an independent predictor of mortality risk. The findings underline that lung cancer in never smokers differs clinically and prognostically from smokers, with implications for personalized management.<br /><br />The authors emphasize the need for standardized definitions and consistent collection of smoking history data to optimize treatment planning and improve lung cancer care. This large Australian registry study provides real-world evidence that smoking status significantly impacts lung cancer survival outcomes across different histologic subtypes.

Asset Subtitle

Susan Harden

Meta Tag

Speaker Susan Harden

Topic Risk Factors, Risk Reduction & Tobacco Control

Keywords

lung cancer

smoking status

never smokers

ex-smokers

current smokers

non-small cell lung cancer

small cell lung cancer

survival outcomes

Victorian Lung Cancer Registry

Australia