WCLC 2025 - Posters & ePosters-P3.18.84 A Randomized Comparative Effectiveness Trial of Perioperative Physical Activity in Older Adults With Lung Cancer and Their Family Caregivers

P3.18.84 A Randomized Comparative Effectiveness Trial of Perioperative Physical Activity in Older Adults With Lung Cancer and Their Family Caregivers

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This summary covers the SR2204 randomized comparative effectiveness trial investigating perioperative physical activity in older adults (≥65 years) undergoing lung cancer surgery and their family caregivers (FCGs). Lung cancer surgery often leads to postoperative challenges such as pain, fatigue, reduced pulmonary function, and diminished physical capabilities, especially in older adults. However, limited data exist on interventions promoting functional recovery in this population, and few address the needs of both patients and their caregivers.<br /><br />The Phase 3 multicenter trial enrolls 382 older adults scheduled for lung cancer surgical resection, randomized 1:1 to either telephone-based physical activity coaching or physical activity self-monitoring without coaching. Both groups receive Vivofit 4 pedometers for activity monitoring. Participants and optional FCGs are assessed pre-surgery, at discharge, and at 30-, 60-, and 180-days post-discharge. The primary outcome is change in 6-minute walk distance (6MWT) at 30 days post-discharge. Secondary outcomes include 6MWT at 60 and 180 days, Short Physical Performance Battery (SPPB), patient and FCG self-efficacy and physical function (measured by PROMIS scales), quality of life (FACT-L), surgical outcomes (e.g., readmissions, complications), and effects of daily steps and sarcopenia on recovery.<br /><br />As of August 5, 2025, 183 participants enrolled, including 94 FCGs. A Stakeholder Advisory Committee with patients, surgeons, and others helped optimize recruitment and study procedures. Remote 6MWT and SPPB assessments were introduced to reduce missing data. Participant feedback highlighted mental health benefits of walking, improved patient-FCG relationships, and usefulness of pedometer step counts. Suggestions for improvement included nutrition support, extended follow-up beyond six months, and the potential use of existing pedometer devices like Apple Watch instead of a separate device.<br /><br />This trial, funded by PCORI, aims to inform best practices for enhancing recovery after lung cancer surgery in older adults and support their caregivers through evidence-based physical activity interventions.

Asset Subtitle

Dan Raz

Meta Tag

Speaker Dan Raz

Topic Clinical Trials in Progress

Keywords

SR2204 trial

perioperative physical activity

older adults

lung cancer surgery

family caregivers

randomized comparative effectiveness

6-minute walk test

physical activity coaching

postoperative recovery

PCORI funded