WCLC 2025 - Posters & ePosters-P3.18.85 A Personalized Nutrition and Physical Exercise Intervention to Enhance Early-Stage NSCLC Outcomes: The STARLighT Study

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The STARLighT study investigates the impact of a personalized nutrition and physical exercise intervention delivered via telemedicine on outcomes in early-stage non-small cell lung cancer (NSCLC) patients undergoing systemic treatments. Recognizing the positive effect of lifestyle changes on lung cancer but noting limited clinical evidence on hard endpoints in early disease, this trial aims to determine whether structured lifestyle modifications can improve pathological complete response (pCR) and disease-free survival (DFS).<br /><br />Eligible participants include patients with stage IB to IIIA resectable or resected NSCLC, ECOG performance status 0-1, who are candidates for systemic treatment and willing to use technology. The study involves two cohorts: Cohort A (n=46) undergoing neoadjuvant treatment tested for improvements in pCR and quality of life (QoL), and Cohort B (n=276) receiving adjuvant therapy evaluated for 2-year DFS. Both cohorts receive tailored exercise, nutritional counseling, oral supplementation, and behavioral support, with Cohort B including a control group receiving standard care educational materials.<br /><br />Exercise protocols differ slightly by cohort but include aerobic and resistance training several times per week. Nutritional intervention emphasizes protein intake (1.5 g/kg body weight) and specific supplements such as arginine, nucleotides, omega-3 fatty acids, or whey protein. Behavioral support includes weekly health education delivered through an interactive platform that facilitates bidirectional communication and patient monitoring.<br /><br />The study is conducted across 34 oncology units in Italy with centralized intervention delivery and follow-up planned through 2030. Secondary measures include treatment toxicity, overall survival, response rates, fitness, body composition, psychological distress, sleep habits, and cost-effectiveness.<br /><br />STARLighT anticipates the intervention will double pCR rates and improve DFS, thereby enhancing cure rates in early NSCLC. Funded by the Italian Association for Cancer Research (AIRC), the trial is registered under ClinicalTrials.gov NCT07042724.

Asset Subtitle

Alice Avancini

Meta Tag

Speaker Alice Avancini

Topic Clinical Trials in Progress

Keywords

STARLighT study

personalized nutrition

physical exercise intervention

telemedicine

early-stage non-small cell lung cancer

pathological complete response

disease-free survival

neoadjuvant and adjuvant therapy

protein supplementation

behavioral support