The IASLC 2026 Hot Topic Meeting: Resistance to Immunotherapy is a biannual international meeting dedicated to the latest preclinical and translational advances in the earliest phases of lung carcinogenesis. This meeting brings together leading scientists, clinicians, and multidisciplinary experts to explore the biological foundations of precancerous lesions and early-stage lung tumors.
Over the course of this meeting, we will examine the biological mechanisms underlying primary and acquired resistance to immunotherapy, explore tumor–immune interactions and the role of the tumor microenvironment, and discuss emerging biomarkers and novel therapeutic strategies to overcome resistance. Through expert-led presentations, panel discussions, and interactive sessions, our goal is to bridge cutting-edge discovery with clinical application—accelerating progress toward more durable and effective immunotherapy outcomes for patients.