The IASLC Atlas of EGFR Testing in Lung Cancer is a useful guidebook, aiming to provide pathologists with “know-how” information on EGFR testing, and to provide the clinicians with the “know-why” information on how to interpret the results. From the retrieval and handling of tumor sample to the different available assays, and from interpretation of results to reporting and quality assurance, the atlas is a comprehensive yet user friendly compendium for the general oncology readership. The EGFR Atlas also summarizes the relevant clinical data supporting the application of EGFR testing in patients with either treatment-naïve or EGFR TKI-resistant disease.