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Episode 9: In this episode of JTO Insights, Editor-in-Chief Dr. Alex Adjei and Associate Editor Dr. Tom John speak with authors of two articles published in the August issue of the Journal of Thoracic Oncology. Michael J. Grant, MD, Assistant Professor of Medicine in the Section of Medical Oncology at Yale School of Medicine in New Haven, Connecticut, discusses “ERBB2-Activating Mutations and Co-Occurring Genomic Alterations Contribute to Disease Heterogeneity in Patients With ERBB2-Mutant Lung Cancer.” Christian Rolfo, MD, PhD, Division Director of Medical Oncology and Associate Director for Early Phase Clinical Trials at The James Comprehensive Cancer Center, The Ohio State University, discusses “Molecular Profiling Across 80,000 Patients With Lung Cancer.”

Articles Discussed:
1. ERBB2-Activating Mutations and Co-Occurring Genomic Alterations Contribute to Disease Heterogeneity in Patients With ERBB2-Mutant Lung Cancer
www.jto.org/article/S1556-0864(26)00161-9/fulltext

2. Molecular Profiling Across 80,000 Patients With Lung Cancer
www.jto.org/article/S1556-0864(26)00148-6/fulltext

3. August 2026, Volume 21 Issue 8
www.jto.org/issue/S1556-0864(26)X2007-X

Podcast Hosts:

• Alex A. Adjei, MD, PhD, FACP, Editor-in-Chief, Journal of Thoracic Oncology; Chief, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA
• Thomas John, MBBS, PhD, Associate Editor, Journal of Thoracic Oncology, Deputy Director, Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, Australia

Podcast Guests:

• Michael J. Grant, MD, Assistant Professor of Medicine in the Section of Medical Oncology, Yale School of Medicine, New Haven, Connecticut
• Christian Rolfo, MD, PhD, Division Director of Medical Oncology, Associate Director for Early Phase Clinical Trials, The James Comprehensive Cancer Center, The Ohio State University, Ohio, United States