The IASLC Asia Conference on Lung Cancer (ACLC), October 9-11, 2025 in Ho Chi Minh, Vietnam, will address key regional challenges, including the high prevalence of genetic mutations, environmental risk factors, and disparities in healthcare access. The conference will focus on expanding early detection through low-dose CT and AI, advancing biomarker testing, and fostering multidisciplinary collaboration among medical oncologists, surgeons, radiologists, pulmonologists, radiation oncologists, pathologists, and all healthcare providers involved in the care of patients with thoracic malignancies. Sessions will explore strategies to improve access to targeted therapies, immunotherapy, and innovative surgical and radiotherapy techniques. Additionally, discussions will highlight public health initiatives, tobacco control, and approaches to reduce healthcare disparities. Education, training, and patient advocacy will remain central themes, ensuring a sustainable and patient-centered approach to lung cancer care across Asia.