2023 World Conference on Lung Cancer (Posters)-EP01.01. Evaluation of Perioperative Nintedanib for Lung Cancer with Idiopathic Pulmonary Fibrosis

EP01.01. Evaluation of Perioperative Nintedanib for Lung Cancer with Idiopathic Pulmonary Fibrosis - PDF(Abstract)

Pdf Summary

This study evaluated the use of perioperative nintedanib, an antifibrotic agent, in patients with lung cancer and idiopathic pulmonary fibrosis (IPF) to prevent postoperative acute exacerbation of IPF (IPAE). The study included 11 IPF patients with lung cancer who received perioperative nintedanib treatment and were retrospectively investigated. The patients' ages ranged from 72-81 years and all had a history of heavy smoking. Most patients underwent lobectomy, but other surgical procedures were also performed. The pathological subtypes of the surgical specimens varied. <br /><br />The study found that none of the patients experienced nintedanib-related side effects that led to the cancellation or postponement of surgery. There were no incidences of IPAE or 30-day mortality. However, some postoperative adverse events were observed, including prolonged air leak, surgical site infection, pyothorax, heart failure, and pleurisy. <br /><br />The authors concluded that this study provides initial evidence for the feasibility and safety of perioperative nintedanib treatment in IPF patients with lung cancer. However, further studies are needed to determine the effectiveness and safety of this treatment and to gather more data through prospective verification. This study highlights the potential of nintedanib as an inhibitor of perioperative IPAE and encourages further investigation in larger cohorts. <br /><br />The keywords related to this study are lung cancer, pulmonary fibrosis, and nintedanib. This study falls under the risk factors, risk reduction, and tobacco control track.

Asset Subtitle

Ryusuke Sumiya

Meta Tag

Speaker Ryusuke Sumiya

Topic Risk Factors, Risk Reduction & Tobacco Control

Keywords

perioperative nintedanib

antifibrotic agent

lung cancer

idiopathic pulmonary fibrosis

IPF

postoperative acute exacerbation

IPAE

retrospective investigation

surgical procedures

pathological subtypes