2023 World Conference on Lung Cancer (Posters)-EP01.01. Familial Aggregation in Non-small Cell Lung Cancer

EP01.01. Familial Aggregation in Non-small Cell Lung Cancer - PDF(Abstract)

Pdf Summary

This study aimed to evaluate patterns of familial aggregation in non-small cell lung cancer (NSCLC) patients and its correlation with clinicopathological characteristics. The study included 507 NSCLC patients, with 16.4% having a significant family history of cancer. Familial aggregation was observed with both tobacco-related and non-tobacco-related malignancies, with head and neck cancer, lung cancer, and breast cancer being the most common. Patients with a significant family history of malignancy were more likely to be never smokers and less likely to have a driver mutation. The study concludes that familial aggregation is common in Indian NSCLC patients, especially among never smokers and driver mutation-negative lung cancer patients. Head and neck cancer, lung cancer, and breast cancer are commonly aggregated in families of NSCLC patients. Further studies evaluating genetic susceptibility in NSCLC are warranted and may have implications on screening and treatment.

Asset Subtitle

Sindhura Durga Chitikela

Meta Tag

Speaker Sindhura Durga Chitikela

Topic Risk Factors, Risk Reduction & Tobacco Control

Keywords

familial aggregation

non-small cell lung cancer

NSCLC patients

clinicopathological characteristics

family history of cancer

tobacco-related malignancies

head and neck cancer

breast cancer

never smokers

driver mutation