2023 World Conference on Lung Cancer (Posters)-EP01.01. Gender Differences in Clinical Course and Patient-Reported Outcomes among Patient with Early-Stage Non-Small Cell Lung Cancer

EP01.01. Gender Differences in Clinical Course and Patient-Reported Outcomes among Patient with Early-Stage Non-Small Cell Lung Cancer - PDF(Abstract)

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This study aimed to investigate gender differences in perioperative clinical course and patient-reported outcomes (PRO) among patients with early-stage non-small cell lung cancer (NSCLC) who underwent surgery. A total of 828 patients (351 males, 477 females) were included in the study. Females were more likely to be younger, married, non-smokers, have a satisfying classification, have adenocarcinoma with stage IA1-IA2, and be treated with a minimally invasive approach. After propensity score matching, 118 case-matched pairs were identified. Females had less lymph node dissection, shorter operative time, less intraoperative bleeding, shorter length of postoperative hospital stay, and fewer postoperative pulmonary complications. Although males experienced longer chest tube duration, more lobectomy, and more invasive histology, no statistically significant differences were found. In terms of patient-reported outcomes, females were more likely to report moderate-to-severe pain, disturbed sleep, shortness of breath, and fatigue during the postoperative hospitalization period. After discharge, females reported more disturbed sleep, shortness of breath, cough, and annoyance. Pain levels between genders were comparable. The study concluded that females with early-stage NSCLC who underwent surgery were more likely to have minimally invasive treatment and be discharged without complications. However, they also had a higher proportion of moderate-to-severe symptom burden and function status compared to males, suggesting that perioperative management may need to be adjusted based on gender. Further research is needed to improve tailored management for gender differences in surgical treatment and outcomes.

Asset Subtitle

Haiyu Zhou

Meta Tag

Speaker Haiyu Zhou

Topic Risk Factors, Risk Reduction & Tobacco Control

Keywords

gender differences

perioperative clinical course

patient-reported outcomes

NSCLC

surgery

minimally invasive treatment

complications

symptom burden

perioperative management

surgical treatment