2023 World Conference on Lung Cancer (Posters)-EP01.01. Gender Differences in Clinical Course and Patient-Reported Outcomes among Patient with Early-Stage Non-Small Cell Lung Cancer

EP01.01. Gender Differences in Clinical Course and Patient-Reported Outcomes among Patient with Early-Stage Non-Small Cell Lung Cancer - PDF(Slides)

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This study aimed to investigate gender differences in the perioperative clinical course and patient-reported outcomes (PRO) among patients who underwent surgery for early-stage non-small cell lung cancer (NSCLC). The researchers found that females were more likely to have minimally invasive treatment and be discharged without postoperative complications. However, females also had a higher proportion of moderate-to-severe symptom burden and functional status compared to males. The study suggests that further research on gender differences in surgical treatment and outcomes is necessary to improve tailored perioperative care. <br /><br />Before propensity score matching (PSM), the study included 351 males and 477 females. Females were more likely to be younger, married, non-smokers, have a satisfying ASA classification, have stage IA1-IA2 adenocarcinoma, and be treated with a minimally invasive approach. After PSM, 118 case-matched pairs were identified. Females were significantly associated with less N2 lymph node dissection, shorter operative time, less intraoperative bleeding, shorter length of postoperative hospital stay, and fewer postoperative pulmonary complications than males.<br /><br />In terms of patient-reported outcomes, females reported more moderate-to-severe pain, disturbed sleep, shortness of breath, and fatigue during the 3-day postoperative hospitalization. During the 4-week post-discharge period, females reported more moderate-to-severe disturbed sleep, shortness of breath, cough, and annoyance compared to males. However, there was no significant difference in pain between the genders.<br /><br />Overall, this study found that while females had better perioperative clinical outcomes in terms of minimally invasive treatment and postoperative complications, they also had a higher burden of symptoms and functional impairment. The study highlights the need for further research to better understand gender differences in surgical treatment and outcomes and to develop personalized perioperative care strategies.

Asset Subtitle

Haiyu Zhou

Meta Tag

Speaker Haiyu Zhou

Topic Risk Factors, Risk Reduction & Tobacco Control

Keywords

gender differences

perioperative clinical course

patient-reported outcomes

non-small cell lung cancer

minimally invasive treatment

postoperative complications

symptom burden

propensity score matching

perioperative care strategies