2023 World Conference on Lung Cancer (Posters)-EP01.01. Impact of Smoking on Survival in NSCLC Patients Treated with Chemoimmunoimmunotherapy or Chemotherapy: A Real-world Data Study

EP01.01. Impact of Smoking on Survival in NSCLC Patients Treated with Chemoimmunoimmunotherapy or Chemotherapy: A Real-world Data Study - PDF(Abstract)

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This study aimed to evaluate the effect of smoking status on overall survival (OS) in non-small cell lung cancer (NSCLC) patients treated with chemotherapy (CT) or chemo-immunotherapy (Chemo-IO) drugs. The study analyzed real-world data from the AACR Project GENIE BPC NSCLC v2.0 database.<br /><br />A total of 536 patients diagnosed with stage I-III NSCLC and receiving either CT or Chemo-IO regimens were included in the study. The mean age of the patients was 67.2 years, with 58% being female and 87% being white. Adenocarcinoma was the most common histological subtype (60%), followed by squamous cell carcinoma (12%). Approximately 81% of the patients were ever-smokers, with 13% being current smokers and 12% and 54% being former smokers who had quit within one year and longer than one year from the cancer diagnosis, respectively.<br /><br />The results showed that smoking status did not have a significant effect on OS in both the CT group and the Chemo-IO group. Non-smokers did not have prolonged survival times compared to smokers in either group. On multivariable analysis, smoking status did not significantly impact OS for CT or Chemo-IO patients.<br /><br />In conclusion, this study found that smoking status did not affect overall survival in stage I-III NSCLC patients receiving treatment with chemotherapy or chemo-immunotherapy. The findings highlight the importance of smoking cessation as a primary preventive measure in reducing lung cancer risk, but suggest that smoking status may not be a strong predictor of survival outcomes in NSCLC patients undergoing these treatments.

Asset Subtitle

Ayah Bani Mostafa

Meta Tag

Speaker Ayah Bani Mostafa

Topic Risk Factors, Risk Reduction & Tobacco Control

Keywords

smoking status

overall survival

NSCLC

chemotherapy

chemo-immunotherapy

real-world data

adenocarcinoma

squamous cell carcinoma

lung cancer risk

survival outcomes