2023 World Conference on Lung Cancer (Posters)-EP01.01. Sex Difference Indicate Survival Disparity in Resected NSCLC, from a Large Chinese Cohort

EP01.01. Sex Difference Indicate Survival Disparity in Resected NSCLC, from a Large Chinese Cohort - PDF(Slides)

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A study conducted in China found that there is a survival disparity between males and females with non-small cell lung cancer (NSCLC) who underwent tumor resection. The study included 8,549 patients who underwent R0 lung tumor resection between 2007 and 2017. It was observed that females tend to survive longer than males after surgery, with females having a hazard ratio of 2.05 compared to males. <br /><br />Further analysis showed that the survival disparity between sexes remained in lung adenocarcinoma, with females having a hazard ratio of 1.71 compared to males. However, in the subgroup of lung squamous cell carcinoma, the overall survival of females was numerically inferior but not statistically significant. <br /><br />When analyzing distinct tumor stages, it was found that females in the stage II-IV lung squamous cell carcinoma subgroup had inferior survival compared to males, with a hazard ratio of 0.57. Additionally, the study found that adjuvant chemotherapy showed optimal efficacy in males but hardly benefited females with advanced NSCLC. <br /><br />In conclusion, the study highlights that the survival disparity between females and males with NSCLC differs based on histological types and tumor stages. This suggests that treatment options should be tailored and examined based on the sex of the patient.

Asset Subtitle

Yifan Guo

Meta Tag

Speaker Yifan Guo

Topic Risk Factors, Risk Reduction & Tobacco Control

Keywords

China

NSCLC

tumor resection

survival disparity

males

females

hazard ratio

lung adenocarcinoma

lung squamous cell carcinoma

treatment options