2023 World Conference on Lung Cancer (Posters)-EP02.01. Androgen Receptor Suppresses Lung Cancer Invasion and Cisplatin Resistance via Decreasing TPD52 Expression

EP02.01. Androgen Receptor Suppresses Lung Cancer Invasion and Cisplatin Resistance via Decreasing TPD52 Expression - PDF(Slides)

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In a study conducted at Xiangya Hospital, researchers have discovered that the androgen receptor (AR) can inhibit the invasion of lung cancer cells and increase their sensitivity to cisplatin treatment. This is achieved by downregulating the expression of circular RNA (circRNA) known as circ-SLCO1B7. The reduced expression of circ-SLCO1B7 leads to the release of miR-139-5p, which binds to the messenger RNA of Tumor Protein D52 (TPD52) and reduces TPD52 levels. The researchers confirmed these findings using in vivo data and analysis of human clinical samples.<br /><br />The significance of this study lies in the fact that lung cancer remains the leading cause of cancer-related deaths worldwide. Therefore, finding new targets for effective treatment is vital. The researchers believe that targeting the newly discovered AR/circ-SLCO1B7/miR-139-5p/TPD52 signaling pathway could provide a novel therapeutic strategy for treating non-small cell lung cancer (NSCLC) and restraining its progression. Future research will focus on gaining a better understanding of the mechanisms behind the association between AR and NSCLC progression.<br /><br />The document also includes several figures and results from the study. Figure 4 demonstrates the role of the AR/circ-SLCO1B7 axis in reducing lung cancer progression by releasing miR-139-5p. Figure 5 shows how this axis can suppress lung cancer cell progression by altering TPD52 expression. Figure 6 presents data from a clinical study that supports the involvement of the AR/circ-SLCO1B7/miR-139-5p/TPD52 signaling pathway in lung cancer progression in human patients. Lastly, Figure 7 depicts the effects of knocking down AR and circ-SLCO1B7 on metastasis and TPD52 expression in an in vivo mouse model.<br /><br />Overall, the study highlights the potential implications of AR in lung cancer treatment and provides valuable insights into the AR/circ-SLCO1B7/miR-139-5p/TPD52 signaling pathway as a therapeutic target for NSCLC. Further research is needed to fully understand and utilize this pathway for potential therapeutic interventions.

Asset Subtitle

Shiqing Liu

Meta Tag

Speaker Shiqing Liu

Topic Tumor Biology: Preclinical Biology - Molecular Therapeutic Targets

Keywords

Xiangya Hospital

androgen receptor

invasion of lung cancer cells

cisplatin treatment

circular RNA

circ-SLCO1B7

miR-139-5p

Tumor Protein D52

non-small cell lung cancer

AR/circ-SLCO1B7/miR-139-5p/TPD52 signaling pathway