2023 World Conference on Lung Cancer (Posters)-EP02.01. PEG2000-PLA-Based Nanoscale Polymeric Micellar Reduces Paclitaxel-Related Toxicity in Beagles

EP02.01. PEG2000-PLA-Based Nanoscale Polymeric Micellar Reduces Paclitaxel-Related Toxicity in Beagles - PDF(Slides)

Pdf Summary

The study aimed to evaluate the toxicological profile of polymeric micellar paclitaxel (Pm-Pac) in beagles. The researchers conducted acute toxicity tests, short-term and long-term toxicity tests on a total of 27 beagles. The results showed that the lethal dosage of Pm-Pac for beagles was between 20-30 mg/kg, with the digestive system and immune-hematopoietic system being the targeted organs for acute toxicity. <br /><br />In the short-term toxicity test, it was observed that the toxicity induced by paclitaxel, such as peripheral neuropathy, hematopoietic toxicity, and heart system toxicity, could be reduced when delivered via the Pm deliver system. In the long-term toxicity test, Pm-Pac was found to reduce hematopoietic toxicity in beagles. <br /><br />The study provided a comprehensive toxicity profile of Pm-Pac in beagles and suggested its potential for reducing toxicity in future clinical applications. The findings contribute to the understanding of nanoplatform-based drug delivery and support the use of Pm-Pac in combination strategies in clinical practice.

Asset Subtitle

Jun Lu

Meta Tag

Speaker Jun Lu

Topic Tumor Biology: Preclinical Biology - Molecular Therapeutic Targets

Keywords

polymeric micellar paclitaxel

toxicological profile

beagles

acute toxicity tests

short-term toxicity tests

long-term toxicity tests

lethal dosage

digestive system

immune-hematopoietic system

Pm deliver system