false
Catalog
2023 World Conference on Lung Cancer (Posters)
EP02.01. Suppression of Telomerase RNA Component I ...
EP02.01. Suppression of Telomerase RNA Component Induces Autophagy and Ferroptosis in Lung Cancer via Regulation of AMP-actived Protein Kinase - PDF(Slides)
Back to course
Pdf Summary
Long non-coding RNAs (lncRNAs) play a role in the development of tumors, including lung adenocarcinoma (LUAD). One specific lncRNA called telomerase RNA component (TERC) is important for the addition of telomere repeats, and dysfunction of TERC has been linked to various human diseases. However, the impact of TERC dysregulation on LUAD progression is not well understood.<br /><br />This study aimed to investigate the effects of TERC expression and activity on LUAD. The researchers used RNA sequencing to compare the levels of TERC in cancerous and normal lung tissues. They also performed functional assays in LUAD cell lines using siRNA to knockdown TERC expression.<br /><br />The results showed that TERC was upregulated in lung cancer tissues and LUAD cell lines. Knockdown of TERC inhibited the growth, migration, and invasion of LUAD cells. Additionally, TERC knockdown induced autophagy, as evidenced by increased expression of autophagy-related proteins and the formation of autophagosomes. It also activated ferroptosis, a form of cell death involving the accumulation of reactive oxygen species (ROS). Knockdown of TERC reduced the expression of ferroptosis inhibitors and resulted in defects in mitochondrial morphology.<br /><br />Furthermore, the study investigated the relationship between TERC and AMP-activated protein kinase (AMPK), a key regulator of autophagy and ferroptosis. Knockdown of AMPK reduced the expression of autophagy-related proteins, and simultaneous knockdown of TERC and AMPK counteracted the effects of TERC knockdown on autophagy and ferroptosis.<br /><br />Overall, this study suggests that dysregulation of TERC is associated with the development of lung cancer. TERC may play a role in autophagy and ferroptosis through the regulation of AMPK-mediated signaling. Further research is needed to understand the exact mechanisms of TERC function and its clinical significance in lung cancer.
Asset Subtitle
wenmei su
Meta Tag
Speaker
wenmei su
Topic
Tumor Biology: Preclinical Biology - Molecular Therapeutic Targets
Keywords
lncRNAs
lung adenocarcinoma
TERC
autophagy
ferroptosis
lung cancer
AMPK
RNA sequencing
knockdown
mitochondrial morphology
×
Please select your language
1
English