2023 World Conference on Lung Cancer (Posters)-EP02.02. Microbiome in Lung Cancer: Culture-Based Analysis Using Transthoracic Needle Biopsy (TTNB)

Pdf Summary

A study conducted at Chungnam National University Hospital in South Korea aimed to analyze the microbiome in lung cancer using a culture-based analysis method called Transthoracic Needle Biopsy (TTNB). The human microbiome refers to the genetic material of the bacteria, fungi, protozoa, and viruses that reside within the human body. Previous research has suggested that the lung microbiome plays a significant role in the development and progression of lung cancer, as well as in determining the response to immunotherapy. However, limited studies have investigated the clinical importance of specific microbiome strains in lung cancer patients.<br /><br />In this study, the researchers analyzed 178 cases of TTNB performed between July 2019 and April 2021. Microbiological culture was conducted on tissue samples obtained through TTNB, and the identified organisms were studied in relation to the prognosis of the lung cancer patients. Out of the 141 cases diagnosed with primary lung cancer, microbiome strains were identified in 25 cases. The most frequently identified organisms were Streptococcus, followed by Staphylococcus, Klebsiella pneumonia, and Actinomyces. Other strains such as Bacillus, Chryseobacterium, Microbacterium, Rothia, and Serratia were also identified.<br /><br />Although no significant correlation was found between the overall survival or best response and the cultured microorganisms, this study provided a novel approach to culturing microorganisms from lung cancer tissues obtained through TTNB. By utilizing aseptic procedures during sample collection, the risk of contamination was minimized. The results indirectly supported the hypothesis that the microbiome may play a role in lung cancer biology. To further advance the understanding of the microbiome in lung cancer, future studies should aim to increase the sample size and employ additional analysis methods such as rRNA gene analysis.<br /><br />Overall, this study contributes to the field by providing evidence for the presence of microorganisms in lung cancer tissue and highlighting the potential importance of the microbiome in the pathogenesis of lung cancer.

Asset Subtitle

So-yun Kim

Meta Tag

Speaker So-yun Kim

Topic Tumor Biology: Preclinical Biology - Omics Approaches

Keywords

Chungnam National University Hospital

microbiome analysis

lung cancer

Transthoracic Needle Biopsy

human microbiome

lung microbiome

immunotherapy response

microbiome strains

prognosis

microbiological culture