2023 World Conference on Lung Cancer (Posters)-EP02.04. A Nanoplatform Based on an in Situ Tumor Vaccine and Activation of STING and TLR7/8 Pathways for Enhanced NSCLC Immunotherapy

EP02.04. A Nanoplatform Based on an in Situ Tumor Vaccine and Activation of STING and TLR7/8 Pathways for Enhanced NSCLC Immunotherapy - PDF(Abstract)

Back to course

Pdf Summary

This study presented a new approach for enhancing immunotherapy in non-small cell lung cancer (NSCLC). The researchers developed a multifunctional nanopolymer called PEG-Ce6@PAEMA/R848, which consisted of a photosensitizer, a pH-sensitive polymer, and an immune adjuvant. The nanopolymer was designed to stimulate the immune system and induce an anti-tumor response.<br /><br />The researchers validated the activation of bone marrow-derived DC cells in vitro and observed the maturation of lymph node DCs and tumor sites in vivo. They also demonstrated that the nanoparticles were successfully synthesized and had acid-responsive and toxic effects. In animal models, significant tumor shrinkage and infiltration of CD8 cells in tumor sites were observed after treatment with the nanopolymer.<br /><br />The study concluded that the nanopolymer-based in situ tumor vaccine could inhibit tumor growth, induce immunogenic cell death, and stimulate a systemic anti-tumor immune response. The researchers plan to further investigate the therapeutic effect on metastatic and distal tumors.<br /><br />Nanomedicine and immunotherapy were identified as keywords for this study. The research falls under the track of Tumor Biology - Preclinical Biology at the World Conference on Lung Cancer (WCLC) 2023. The session focused on tumor immunity and the use of preclinical models to study tumor biology.

Asset Subtitle

Haiyu Zhou

Meta Tag

Speaker Haiyu Zhou

Topic Tumor Biology: Preclinical Biology - Tumor Immunity

Keywords

immunotherapy

NSCLC

nanopolymer

tumor response

animal models

tumor shrinkage

in situ tumor vaccine

immunogenic cell death

systemic anti-tumor immune response

tumor biology