2023 World Conference on Lung Cancer (Posters)-EP02.04. PHLPP2 Enhances Anti-tumor Immunity by Promoting M1 Polarization of Macrophages via STAT3-related Pathway in NSCLC

EP02.04. PHLPP2 Enhances Anti-tumor Immunity by Promoting M1 Polarization of Macrophages via STAT3-related Pathway in NSCLC - PDF(Slides)

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This study explores the relationship between the tumor suppressor gene PHLPP2 and immunity in lung cancer. The researchers found that PHLPP2 is related to the tumor microenvironment and the content of tumor-associated macrophages (TAM). They performed experiments on lung cancer cells and found that overexpression of PHLPP2 reduced the migration of immune cells and increased the expression of anti-tumor macrophages. Further investigation revealed that this effect was related to the STAT3 immune signaling pathway. These findings suggest that the expression of PHLPP2 in lung cancer cells can promote the polarization of anti-tumor macrophages through STAT3-related pathways. Overall, this study highlights the potential of targeting PHLPP2 as a therapeutic approach in lung cancer immunotherapy.

Asset Subtitle

Haihua Yang

Meta Tag

Speaker Haihua Yang

Topic Tumor Biology: Preclinical Biology - Tumor Immunity

Keywords

tumor suppressor gene

PHLPP2

immunity

lung cancer

tumor microenvironment

tumor-associated macrophages

migration of immune cells

anti-tumor macrophages

STAT3 immune signaling pathway

polarization of anti-tumor macrophages