2023 World Conference on Lung Cancer (Posters)-EP03.01. Genetic Alterations as Independent Prognostic Factors to Predict Organ-Specific Metastases of Lung Cancer

EP03.01. Genetic Alterations as Independent Prognostic Factors to Predict Organ-Specific Metastases of Lung Cancer - PDF(Abstract)

Back to course

Pdf Summary

This presentation discusses the genetic alterations that may serve as independent prognostic factors to predict organ-specific metastases in lung cancer patients. The study aimed to analyze the genomic features of primary tumors in lung cancer patients and compare them with the clinical information of distant metastases to the brain, liver, and/or bone.<br /><br />The researchers retrospectively selected patients with lung cancer distant recurrence from the North Estonia Medical Centre Thoracic Tumors' Database. Whole exome sequencing was performed on the histological specimens of these patients to analyze small genetic alterations, including single nucleotide polymorphisms (SNPs) and insertion-deletion mutations (INDELs).<br /><br />The study included 69 patients with distant recurrence, with 18 patients having brain metastases, 13 patients having liver metastases, and 16 patients having bone metastases. Several significantly mutated genes were identified in each metastatic group. In the brain metastases group, the most significant gene alterations were TMEM64 and ZDHHC9 mutations. In the liver metastases group, RUNX1T1 and PKMYT1 mutations were identified as the most significant. In the bone metastases group, PCGF5 was found to be significantly altered.<br /><br />The researchers also performed gene enrichment analysis, which revealed specific biological functions related to the different metastatic sites. For example, terms related to tubuline and cytoskeletal protein bonding were enriched in the brain metastases group, while terms related to microtubules and motile cilium were enriched in the liver metastases group.<br /><br />Overall, this study emphasizes the distinct genomic features of cancer cells that may contribute to their ability to metastasize to specific organs in lung cancer. The identified genetic alterations in primary tumors could potentially serve as predictive markers for specific organ metastases. However, further analysis and validation are needed to better understand the mechanisms of site-specific metastases and improve the management of lung cancer patients.

Asset Subtitle

Ann Valter

Meta Tag

Speaker Ann Valter

Topic Tumor Biology: Translational Biology - Disease Modeling

Keywords

genetic alterations

prognostic factors

organ-specific metastases

lung cancer patients

genomic features

primary tumors

distant metastases

brain metastases

liver metastases

bone metastases