2023 World Conference on Lung Cancer (Posters)-EP03.01. The Role of Microenvironmental Biomechanics in Lung Cancer Development and Metastasis

EP03.01. The Role of Microenvironmental Biomechanics in Lung Cancer Development and Metastasis - PDF(Abstract)

Pdf Summary

This presentation at WCLC 2023 titled "The Role of Microenvironmental Biomechanics in Lung Cancer Development and Metastasis" explores the relationship between mechanical properties and migration characteristics of lung adenocarcinoma cells. The study aims to understand the development and metastasis of lung cancer cells in different mechanical microenvironments. The researchers used atomic force microscopy (AFM) to analyze stiffness heterogeneity in pulmonary nodules with different imaging manifestations. They also investigated the effects of matrix stiffness on cancer cells using a cell culture system with tunable rigidity. The results showed that matrix stiffness had a significant impact on actin organization, cell migration, and proliferation of cancer cells. These findings highlight the unique biomechanical features of the lung cancer microenvironment. Understanding these characteristics can provide insights into the development of lung adenocarcinoma nodules and inform targeted interventions. The research has both basic research significance and potential clinical implications for understanding the influence of physical factors in the tumor microenvironment and developing effective treatments for lung cancer.

Asset Subtitle

Jian Gao

Meta Tag

Speaker Jian Gao

Topic Tumor Biology: Translational Biology - Disease Modeling

Keywords

microenvironmental biomechanics

lung cancer development

metastasis

mechanical properties

lung adenocarcinoma cells

matrix stiffness

cell migration

actin organization

biomechanical features

tumor microenvironment