2023 World Conference on Lung Cancer (Posters)-EP03.01. The Role of Microenvironmental Biomechanics in Lung Cancer Development and Metastasis

Pdf Summary

The study conducted by Jian Gao from Peking University in China focuses on the role of microenvironmental biomechanics in the development and metastasis of lung cancer. The research utilized CT imaging to analyze lung nodules with different densities and clinicopathologic features. It was found that there were differences in infiltration and lymph node metastasis among the different types of nodules, namely Solid Nodule, SD Part-solid Nodule, Pure Ground Glass Nodule. <br /><br />The study also employed techniques such as atomic force microscopy (AFM) and traction force microscopy (TFM) to investigate the stiffness heterogeneity in pulmonary nodules. In vitro cell culture systems using polyacrylamide gel with tunable rigidity were used to observe the effects of matrix stiffness on cancer cells, including changes in actin organization, cell migration, proliferation, and cellular traction.<br /><br />Additionally, three-dimensional cell culture models were used to assess changes in cell morphology and microfilament skeleton due to osmotic pressure. It was found that matrix stiffness plays a significant role in cancer metastasis and alters mechanotransduction pathways.<br /><br />These findings suggest the presence of unique biomechanical features in the lung cancer microenvironment. The study implies that understanding the development of lung adenocarcinoma nodules, exploring the influence of physical factors in the tumor microenvironment on lung cancer, and developing targeted interventions can have significant research and clinical translation prospects.<br /><br />In conclusion, the study conducted by Jian Gao provides valuable insights into the role of microenvironmental biomechanics in lung cancer development and metastasis. The findings have the potential to contribute to a better understanding of lung cancer and the development of targeted interventions.

Asset Subtitle

Jian Gao

Meta Tag

Speaker Jian Gao

Topic Tumor Biology: Translational Biology - Disease Modeling

Keywords

microenvironmental biomechanics

lung cancer

CT imaging

lung nodules

infiltration

lymph node metastasis

atomic force microscopy

traction force microscopy

matrix stiffness

mechanotransduction pathways